Application of capillary zone electrophoresis for the characterization of antibody-oligo conjugates Analytical tests that can be utilized for the characterization of antibody-oligonucleotide complexes (AOCs) include gel exclusion chromatography, SDS-PAGE, mass spectrometry, and capillary electrophor... 29 Apr 2025
IN-DEPTH: IN-situ DEtailed Phenotyping To High Resolution IN-DEPTH: IN -situ DE tailed P henotyping to H igh Resolution Introduction In the evolving field of biomarker discovery and spatial biology, IN -situ DE tailed P henotyping T o Hi gh Resolution (IN-DE... 8 Apr 2025
Site-directed antibody conjugation methods 1: application of transglutaminase in the production of antibody-oligo conjugates Transglutaminase catalyses the formation of an isopeptide bond between a lysine (K) residue and the γ-carboxamide group of a glutamine (Q) residue. The microbial (mTGase) rather than the eukaryotic en... 2 Apr 2025
Degree of Labeling Impacts AOCs for Single-Cell Multi-Omics Degree of Labeling Impacts AOCs for Single-Cell Multi-Omics If you’ve ever tried single-cell RNA sequencing (scRNA-seq), you know the struggle, transcriptomics alone doesn’t always give the full pictu... 25 Mar 2025
Scientific Techniques Using Antibody-Oligonucleotide Conjugates Antibody-Oligonucleotide Conjugate Technology Development Antibody-oligonucleotide conjugation has revolutionized molecular detection since the 1992 introduction of Immuno-PCR, achieving femtomolar se... 12 Mar 2025
Achieving batch-to-batch consistency with Antibody Oligonucleotide Conjugates (AOCs) Batch-to-batch consistency in antibody conjugate production is challenging with any type of label and can only be achieved with tight control of multiple reaction parameters. While the degree of label... 4 Mar 2025
Smart application of an old conjugation reagent in the production of AOCs Antibody-oligonucleotide conjugates (AOCs) are used in techniques such as immuno-PCR, proximity ligation assay (PLA) and proximity extension assay (PEA), and are also being examined as potential thera... 25 Feb 2025
Fine Tuning Your Antibody-Oligonucleotide Conjugates (AOC) Antibody-oligonucleotide conjugates (AOCs) are at the forefront of protein detection and analytical assays, enabling high-throughput and multiplexed analysis. As AOCs are highly tunable it is critical... 18 Feb 2025
Optimizing Antibody Oligo-Conjugates Staining for Single-Cell Multiomics In the fast-evolving landscape of multimodal single-cell analysis, antibody oligo -conjugates (AOCs) have revolutionized our ability to simultaneously profile gene expression and surface protein marke... 11 Feb 2025
Should We Barcode All Research Antibodies with Oligos? We all want more data! Multiplex Assays are accelerating scientific discovery. We also need the sensitivity to detect low abundance proteins in tiny samples (and even single cells)! The quest to under... 7 Feb 2025